CHAPTER 5 – THE INTEGUMENTARY SYSTEM OBJECTIVES AND LECTURE OUTLINE OBJECTIVES – At the conclusion of this chapter, the student should be able to: Name the two major layers of the skin and the tissue of which each is made State the locations and describe the functions of the stratum germinativum and stratum corneum Describe the function of the Langerhans cells Describe the function of melanocytes and melanin Describe the functions of hair and nails Name the cutaneous senses and explain their importance Describe the functions of the secretions of sebaceous glands, ceruminous glands, and eccrine sweat glands. Describe how the arterioles in the dermis respond to heat, cold, and stress Name the tissues that make up the subcutaneous tissue, and describe their functions LECTURE OUTLINE Introduction The integumentary system consists of the skin and its accessory structures and the subcutaneous tissue. The two major layers of the skin are the outer epidermis and the inner dermis. Epidermis – made of stratified squamous epithelium; no capillaries; cells called keratinocytes – have tight junctions between them, and are a first line of defense – Figures 5-1 and 5-2 and Table 5-1 Stratum Germinativum – the innermost layer where mitosis takes place – new cells produce keratin and die as they are pushed toward the surface o keratinocytes synthesize defensins (antimicrobial peptides produced when the skin is injured) o Vitamin D is formed from cholesterol on exposure to the UV rays of
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- Spring '16