Key Concepts vDec2.pdf - Some Key Concepts from Drugs and the Brain Fall 2014 Useful as a guide for study Not intended to be an exhaustive list Lecture

Key Concepts vDec2.pdf - Some Key Concepts from Drugs and...

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“Drugs and the Brain” Fall 2014 Key Concepts - 1 Some Key Concepts from “Drugs and the Brain” – Fall 2014 Useful as a guide for study; Not intended to be an exhaustive list Lecture 1 (8/28) • physicalism, world view • drug, droog, psychoactive drug • pharmaco, pharmakon • ethnobotany • power plants, plant teachers, ally • war on drugs, war on plants • drug war arrests • funding for prisons vs. finding for education Lecture 2 (9/2) • George Bush’s Presidential Address on National Drug Policy, 1989 • Paracelsus • routes of drug entry into body • oral-digestive • hepatic portal system, first-pass metabolism • parenteral routes: intraoral, intranasal, rectal, transdermal, inhalation, injection • times of absorption • dangers associated with injections • elimination from body: liver, kidneys Lecture 3 (9/4) • brain, brain cells: neurons, glia • blood-brain barrier • crossing BBB: transport, diffusion • phospholipid bilayer cell membrane • chemistry, alchemy • chemical element, periodic table • cyclotron • Ernest Lawrence • molecules, covalent chemical bonds • bonds per atom: carbon, nitrogen, oxygen, hydrogen • water, polarity • hydrocarbon • understanding molecular structure diagrams
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“Drugs and the Brain” Fall 2014 Key Concepts - 2 Lecture 4 (9/9) • understanding molecular structure diagrams, continued • phospholipid bilayer cell membrane, continued • hydrophilic, hydrophobic, lipophilic, lipophobic • blood-brain barrier by diffusion • neuron, synapse, neurotransmitter, receptor protein • presynaptic and postsynaptic components of synapse • agonist, antagonist • central nervous system, peripheral nervous system • autonomic nervous system • sympathetic and parasympathetic actions • acetylcholine, norepinephrine • sympathomimetic, sympatholytic, parasympathomimetic, parasympatholytic • pupil dilation: mechanism, pharmacology Lecture 5 (9/11) • solanaceous plant family • tomato, potato, eggplant, chili • Carl von Linné, Linnaeus • alkaloid properties • tropane alkaloids: atropine, scopolamine • acetylcholine receptors (AChR): muscarinic, nicotinic • muscarinic AChR antagonists: effects, uses • hallucination, hallucinogen • deadly nightshade: Atropa belladonna • mandrake, henbane, datura • angel’s trumpet: Brugmansia Nicotiana tabacum Lecture 6 (9/16) • tobacco, Nicotiana tabacum • Thanatopathia • routes of administration • shamanic / therapeutic uses • Richard Evans Schultes • Jean Nicot • James I Nicotiana rustica • nicotine • nicotinic acetylcholine receptor • acute effects of nicotine and tobacco • LD-50 • toxic effects of nicotine and tobacco: chronic effects on health • tobacco-related mortality in USA
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“Drugs and the Brain” Fall 2014 Key Concepts - 3 Lecture 7 (9/18)
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