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Lecture 10 - Neurons and Membrane Potential Spring 08

Lecture 10 - Neurons and Membrane Potential Spring 08 -...

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Long Distance Communication – Nervous System Neurotransmitter (chemical)
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Structure of a Typical Neuron
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Graded Potentials Target Dendrites or Cell Body Receptive region Secretory region Conducting region
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Abundance of Synapses on a Postsynaptic Neuron
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Structure of a Chemical Synapse
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Events at a Chemical Synapse Figure 821, p. 271
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Distribution of Water and Solutes 1) Water is able to distribute evenly throughout body - body at “Osmotic Equilibrium” 2) Movement of solutes restricted by transport properties of cell membrane – body is at “Chemical Disequilibrium” ECF ICF
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Inside Cell [Na + ] 15 mM [Cl - ] 10 mM Outside Cell [A - ] (Pr - ) 190 mM [K + ] 150 mM [Na + ] 150 mM [K + ] 5 mM [A - ] (Pr - ) 0.2 mM [Cl - ] 120 mM The Basis of the Resting Membrane Potential [Ca 2+ ] 2.5 mM [Ca 2+ ] 0.001 mM
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Separation of Electrical Charge -1 +1
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Separation of Electrical Charge -1 +1
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Cell membrane Microelectrode inside cell Microelectrode outside cell Voltmeter + + + + + + + + + + + + + + + + + - - - - - - - - - - - - - - - - - - 70 mV Measuring Resting Potential Difference Across Cell Membrane
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Potassium Equilibrium Potential Equilibrium Potential = Electrical gradient exactly opposes the K + concentration gradient +1 -1
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Inside Cell [Na + ] 15 mM [Cl - ] 10 mM Outside Cell [A - ] (Pr - ) 190 mM [K + ] 150 mM [Na + ] 150 mM [K + ] 5 mM [A - ] (Pr - ) 0.2 mM [Cl - ] 120 mM The Basis of the Resting Membrane Potential [Ca 2+ ] 2.5 mM [Ca 2+ ] 0.001 mM
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Lecture 10 - Neurons and Membrane Potential Spring 08 -...

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