7a2d0afbafcc27a8eacf32e6dfbea451_58df978dfa3489e180de5fea4590131c.docx - Q Write a one to two-sentence description of a matrix drug-delivery system and

7a2d0afbafcc27a8eacf32e6dfbea451_58df978dfa3489e180de5fea4590131c.docx

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Q: Write a one- to two-sentence description of a matrix drug-delivery system and a reservoir drug- delivery system. Use a diagram, if that is helpful. So what are the defining features of a reservoir drug-delivery system? Literally, the system has a reservoir – aka, a chamber-like component that houses the drug usually in liquid form. This “core” of the drug is surrounded/encased in a film made of certain types of polymer – usually biocompatible. The chemical characteristics of the polymer (such as the molecular composition of the polymer – if it’s a pretty densely branched repeating chain of molecules ( that is essentially what a polymer is) vs. a less branched chain of repeating molecular chain) and the physical properties of the polymer (such as how thick vs. thin the film is) can affect the rate of the drug within being released through the polymer coating of the reservoir. The physical / chemical properties of the drug molecules that would interact with the physical / chemical properties of the encasing polymer membrane can influence the rate of the drug diffusing through the membrane out of the reservoir and into the external environment. The path that the drug molecule takes is: dissolution of drug from the core into the surrounding polymer diffusion of the drug across the polymer membrane dissolution of drug into the external environment. So what’s a matrix drug-delivery system like? This type of drug-delivery system also utilizes polymers but in a different way: the polymer doesn’t serve as an enclosing membrane to the drug core, but the polymer – usually biocompatible so that it can be placed directly in the vicinity of the target region in the body - is actually the ‘chunk’ in which drug molecules are evenly dispersed/dissolved throughout the chunk. And when the matrix delivery system – aka the ‘chunk’ of polymer that contains drug molecules
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