ALZHEIMER'S STUDY GUIDE FOR exam 3.docx - ALZHEIMERS DISEASE PG 946 What is Alzheimers Chronic progressive degenerative disease of the brain No cure


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ALZHEIMER’S DISEASE PG 946 What is Alzheimer’s? Chronic, progressive, degenerative disease of the brain No cure! Triples health-care costs for Americans ages 65> What causes Alzheimer’s? Cause is unknown Age >65 (biggest risk) , gender, head injury, heart and head connection, and family history are the most important risk factors What areas of the brain are affected? First is the hippocampus , then precentral gyrus, superior temporal gyrus, and substantia nigra What changes are seen in the brain in a patient with AD? Neurofibrillary tangles o Tangled masses of fibrous tissue throughout the neurons o Hallmark pathology o Twisted strands of another protein Neuritic plaques o Beta-amyloid o Sticky o Inflammation Chemical changes o AcH is decreased Clinical manifestations of someone with Alzheimer’s? Changes in cognition o One of the first symptoms of AD is short-term memory impairment o Attention, learning, perception, concentration, and language are affected
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