lecture 1-27 pedigrees, human gen[1].

lecture 1-27 pedigrees, human gen[1]. - The Multiplication...

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The Multiplication and Addition Rules Applied to Monohybrid Crosses The multiplication rule States that the probability that two or more independent events will occur together is the product of their individual probabilities • Example: The odds of a couple, each heterozygous, having a homozygous recessive child is ¼, the odds of that child being a male and homozygous recessive is ½ x ¼ , or 1/8. The rule of addition - States that the probability that any one of two or more exclusive events will occur is calculated by adding together their individual probabilities Example: The odds of a couple, each heterozygous, having a heterozygous child is ¼ + ¼ , or ½.
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Learning objectives Chapters 14 Be able to construct/analyze a pedigree to deduce genotypes. Know examples of human disorders that are recessively inherited and dominantly inherited. Describe two methods of fetal testing for inherited diseases. ---------------------------------------- Chapter 15 (pp282-288) Recognize the inheritance patterns of sex-linked genes. Know examples. Know the chromosomal basis of sex differs in different animal groups. Explain X inactivation in female mammals including examples. Describe examples of chromosomal alterations that cause genetic disorders. Recall meiotic nondisjunction and how it may lead to monosomy, trisomy, or aneuploidy. Know the examples of Turner syndrome, Klinefelter syndrome, and Down’s syndrome.
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Figure 15.10 The transmission of sex-linked recessive traits X A X A X a Y × X a Y X A X a X A Y X A Y X A Y a X A X A Ova Sperm X A X a X A Y Ova X A X a X A X A X A Y X a Y X a Y A X A Y Sperm X A X a X a Y × × Ova X a Y X A X a X A Y X a Y X a Y a X A X a A father with the disorder will transmit the mutant allele to all daughters but to no sons. When the mother is a dominant homozygote, the daughters
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lecture 1-27 pedigrees, human gen[1]. - The Multiplication...

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