lecture 4-21 immune sys III

lecture 4-21 immune sys III - A survey of innate and...

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A survey of innate and acquired immunity INNATE IMMUNITY Rapid responses to a broad range of microbes ACQUIRED IMMUNITY Slower responses to specific microbes External defenses Internal defenses Skin Mucous membranes Secretions Phagocytic cells Antimicrobial proteins Inflammatory response Natural killer cells Humoral response (antibodies) Cell-mediated response (cytotoxic lymphocytes) Invading microbes (pathogens) Figure 43.2 Monday’s topic Wednesday’s topic Today’s topic
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Chapter 43 – Immune system: Cell-mediated immune response Learning objectives • Understand how antibodies remove antigens • Know the general structure of the T cell receptor site for an antigen epitope • Describe the roles of helper T lymphocytes in both humoral and cell-mediated immunity. • Describe the role of cytotoxic T cells. • Distinguish between T-dependent antigens and T-independent antigens. • List three autoimmune disorders • Distinguish between inborn and acquired immunodeficiency. • Explain how general health and mental well-being might affect the immune system.
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Antibody-mediated mechanisms of antigen disposal Binding of antibodies to antigens inactivates antigens by Viral neutralization (blocks binding to host) and opsonization (increases phagocytosis) Agglutination of antigen-bearing particles, such as microbes Precipitation of soluble antigens Activation of complement system and pore formation Bacterium Virus Bacteria Soluble antigens Foreign cell Complement proteins MAC Pore Enhances Phagocytosis Leads to Cell lysis Macrophage Figure 43.19
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An overview of the major roles in the acquired immune response Figure 43.14 Humoral immune response Cell-mediated immune response First exposure to antigen Intact antigens Antigens engulfed and displayed by dendritic cells Antigens displayed by infected cells Activate Activate Activate Gives rise to Gives rise to Gives rise to B cell Helper T cell Cytotoxic T cell Plasma cells Memory B cells Active and memory helper T cells Memory cytotoxic T cells Active cytotoxic T cells Secrete antibodies that defend against pathogens and toxins in extracellular fluid Defend against infected cells, cancer cells, and transplanted tissues Secreted cytokines activate
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This note was uploaded on 03/19/2008 for the course BIO 311D taught by Professor Reichler during the Spring '08 term at University of Texas.

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lecture 4-21 immune sys III - A survey of innate and...

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