Lecture 6.docx - Lecture 6 Tropane alkaloids(contains a basic nitrogen o Atropine(hyoscyamine Muscarinic acetylcholine receptor antagonists

Lecture 6.docx - Lecture 6 Tropane alkaloids(contains a...

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9/12/17 Lecture 6 Tropane alkaloids (contains a basic nitrogen) o Atropine (hyoscyamine) Muscarinic acetylcholine receptor antagonists Parasympatholytic = blocks the parasympathetic nervous system Passes the blood-brain barrier Comes from Solanaceous plant family ( Atopa belladonna ; deadly nightshade) Is a poison o Scopolamine Alkaloid = a naturally occurring organic chemical usually containing a basic nitrogen, which will pick up a positive charge o Examples: atropine, morphine o Basic = will pick up a positive charge (not a permanent charge—will go away when the environment of positive charge is removed) o Often has a bitter taste When receptors in human tongue are stimulated by alkaloid molecules, they produce a bitter taste to serve as warning that alkaloids are poisons o Plants may manufacture alkaloids as a defense against insects and other predators Acetylcholine (cholinergic) synapse o Two major types of acetylcholine receptors:
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