EPI 201 Lab 7 Practice Problem Solutions.pdf - Epi 201 Lab 7 Practice Problems 1 You decide to look at a cohort of people from 2000-2010 to assess

EPI 201 Lab 7 Practice Problem Solutions.pdf - Epi 201 Lab...

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Epi 201 Lab 7 Practice Problems 1. You decide to look at a cohort of people from 2000-2010 to assess whether aspirin use at baseline is associated with 10-year mortality. Discuss what the causal question of interest may be and describe what other information you would want to collect from this cohort and why. NB: Various answers are possible. The following may be informative. o The following three questions all look at the effect of aspirin use, but in different populations: o Causal question: What is the effect of aspirin use (150 mg daily) at baseline on 10-year risk of death in this entire cohort? Counterfactuals you would need to answer this causal question: 10-year risk of death if everyone had used aspirin at baseline 10-year risk of death if nobody had used aspirin at baseline o Causal question: What is the effect of aspirin use (150 mg daily) at baseline on 10-year risk of death among aspirin users? Counterfactuals you would need to answer this causal question: 10-year risk of death if aspirin users had used aspirin at baseline (this is directly observable, assuming consistency) 10-year risk of death if aspirin users had not used aspirin at baseline o Causal question: What is the effect of aspirin use (150 mg daily) at baseline on 10-year risk of death among those who did not use aspirin? Counterfactuals you would need to answer this causal question: 10-year risk of death if those who did not use aspirin at baseline had used aspirin at baseline 10-year risk of death if those who did not use aspirin at baseline had not used aspirin at baseline (this is directly observable, assuming consistency) o Collect information on: Detailed information on aspirin use at baseline Aspirin use should be specified as clearly as possible to satisfy the well-defined intervention criteria Potential confounding variables (e.g. age, gender, SES socioeconomic status , history of cardiovascular disease, diet) Variables that may describe those who become lost to follow-up that may be related to exposure and outcome 2. Assume that there are only three ways to develop type 2 diabetes (T2D): Being obese (O) and having a high intake of red meat (R)
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