BB lecture 11-21 gene regulation - prokaryotes

BB lecture 11-21 gene regulation - prokaryotes - Gene...

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Gene Regulation • Although different cell types have the same genome, uniqueness is due to differential gene expression • So…how is gene expression controlled? - Various mechanisms, for example: > The tight packing of DNA restricts access & prevents transcription
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DNA RNA mRNA Protein    Chemical Modification Control Points for Eukaryotic Genes cytoplasm nucleus
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Recall: Figure 19.2 Levels of chromatin packing 2 nm 10 nm DNA double helix Histone tails His- tones Linker DNA (“string”) Nucleosome (“bead”) Histone H1 (a) Nucleosomes (10-nm fiber) Nucleosome Protein scaffold 30 nm 300 nm 700 nm 1,400 nm (b) 30-nm fiber (c) Looped domains (300-nm fiber) (d) Metaphase chromosome Loops Scaffold
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Review:  Euchromatin  Heterochromatin The structure of chromatin provides a way to control gene expression Heterochromatin = highly condensed, unable to transcribe Euchromatin = relaxed, areas open for transcription What causes chromatin to be  condensed ?
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Histones are proteins with many (+) charged amino acids (Lys &
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Gene Regulation • Although different cell types have the same genome, uniqueness is due to differential gene expression • So…how is gene expression controlled? - Various mechanisms, for example:
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This note was uploaded on 03/19/2008 for the course BIO 311C taught by Professor Satasivian during the Fall '08 term at University of Texas at Austin.

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BB lecture 11-21 gene regulation - prokaryotes - Gene...

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