BiochemF2017.Lecture9.pptx.pdf - Typical Relationship...

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Typical Relationship Between Enzyme Activity and Temperature
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Comparison of Two Proteolytic Enzymes for their Activity Dependence on pH
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pH Dependence of a Hypothetical Enzyme: Related to Ionic State of Important Functional Groups, e.g. COOH, NH 2
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Types of Catalysis by Enzymes 1. Covalent catalysis : reactive group in active site is temporarily covalently modified 2. General acid-base catalysis : a molecule in active site, e.g. a specific amino acid, acts a proton donor or acceptor 3. Metal ion catalysis : Metal ions may A. Act as an electrophile, stabilizing a negative charge on reaction intermediate B. Increase acidity of another molecule like water C. Bind to substrate and facilitate its interaction with enzyme 4. Catalysis by Approximation & Orientation : Allowing two substrates to be brought closer together and in proper orientation by interactions with enzyme
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Mechanisms of Reversible Enzyme Inhibition: Competitive Inhibition Competitive Inhibitors Bind Active Site &
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