Chapter 22- Drugs for lipid disorders.docx

Chapter 22- Drugs for lipid disorders.docx - Chapter 22...

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Chapter 22- lipid disorders 3 primary types: 1. Triglycerides o Comprise 90% of total lipids o Provide fuel for the body during times of need 2. Phospholipids o Essential for plasma membrane Lecithin’s (found in egg yolks/soybeans) No benefit to cholesterol levels by consuming o Contrary to popular belief 3. Steroids o Substances that contain a sterol nucleus Sterol nucleus: ring stucture o Related to atherosclerosis o Eg) Cholesterol: Natural/vital component of plasma membrane Building block for lots of biochemicals: Vit D, Bile, Cortisol, estrogens/testosterone Body makes 75% of blood cholesterol 25% comes from the diet o Only in animal products Humans do not metabolize plant sterols Limit: <300mg/day Lipoproteins- consist of varying amts of cholesterol, triglycerides, and phospholipids bound to a carrier to transport lipids Apoprotein: protein component of the lipoprotein carriers 3 kinds: 1. High density lipoproteins (HDLs) most apoprotein by weight (approx. 50% of mass) m ade in liver/small intestine transports away from tissues back to liver o Called: reverse cholesterol transport Cholesterol component is broken down and united with Bile excreted w/feces o Only excretion route 2. Low Density Lipoproteins (LDLs) Most cholesterol by weight
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Transports cholesterol o From liver tissues and organs used by organs to build plasma membranes/syth. steroids o Can be stored in tissues Leads to plaque build up in arteries coronary artery disease 3. Very low-density lipoproteins (VLDLs) Primary carrier of triglycerides Can be reduced to LDLs Hyperlipidemia : general term for high lipids Hypercholesterolemia : high cholesterol in blood Dyslipidemia: abnormal lipids in blood Can be too high OR too low Reasons for hyperlipidemia: 1. Genetics: a. Lipid metabolism is dictated by genetics 2. Diet: a. Inc. lipid consumption = inc. lipids in blood
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