BIOL201 Chapter 19 Microbial Diseases of the Skin.ppt

BIOL201 Chapter 19 Microbial Diseases of the Skin.ppt -...

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Microbial Diseases of the Skin Chapter 19
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Dendritic cells (DCs) are specialized antigen presenting cells abundant in peripheral tissues such as skin where they function as immune sentinels. Skin DCs migrate to draining lymph node where they interact with naïve T cells to induce immune responses to microorganisms, vaccines, tumors and self-antigens
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S. Epidermidis vs. S. aureus S. epi is most common normal flora. When it causes folliculitis the possibility of the condition advancing is limited. S. aureus poses a much more significant problem due to a range of virulence factors which include: coagulase, hyaluronidase, Staphylokinase, Protein A, and a range of toxin. S. aureus often is antibiotic resistant. S. aureus is an important pathogen in other body systems and will be discussed with those body systems .
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Streptococcus pyogenes Referred to primarily as group A β-hemolytic streptococcus. Produces a number of virulence factors including M protien that interferes with compliment activation, hyalurinic acid capsule, pyrogenic (erythrogenic) toxins Implicated in a number of skin and wound infections along with infection of a the skin and wounds.
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Virulence Factors and Evasion of Body Defenses by Streptococcus pyogenes
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Infections of the Skin Staphylococcus aureus Streptococcus pyogenes Proprionibacterium acnes
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Folliculitis Pimple Furuncle Carbuncle Members of the genus Staphyloccus most common cause Members of the genus Staphylococcus are pyogenic.
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Infections of the Skin Pyogenic bacteria cause accumulation of pus in follical Abscess
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Sty Folliculitis of eye lash Usually caused by S. aureus
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Stapylococcal Scalded Skin Syndrome Usually impacts infants or those with severe disruption of their immune system. Release of exfolliative toxin from S. aureus leads to delamination of the epidermis from dermis. Skin appears to be burned but affected areas are not painful.
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Stapylococcal Scalded Skin Syndrome
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Impetigo Thought to be caused by either S. aureus or Streptococcus pyogenes. In some cases both seem to be present. Raised, reddened lesion. Lesion are pus filled early then rupture and are covered with thick scab that has a yellow-gray crust
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Impetigo
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Streptococcal cellulitis Streptococcus pyogenes infects break in the skin. Pyogenic toxin impacts underlying tissues to produce local reddening of tissues .
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  • Spring '16
  • RobinDonaldson

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