1b The Kidney - Reabsorption.pptx - Renal Physiology...

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Renal Physiology: Glucose Reabsorption Colleen Talbot, Ph.D. Professor of Physiology Basic Medical Sciences, COMP Western University of Health Sciences [email protected] HPC-2264 x8221
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Learning Objectives Be able to describe the structure of an epithelium and know where they are found. Be able to describe the various roles they play in the body, specifically in the kidney Be able to describe how glucose crosses the epithelium of the proximal tubule using transcellular transport Be able to describe what is meant by the TF/P ratio and what changes in that ratio means Be able to define “filtered load” and know how the filtered load changes with changes in plasma concentrations. Be able to calculate the rate of reabsorption across the proximal tubule given the parameters GFR, plasma concentration, urine concentration and urine flow rate Be able to define “Tmax” and relate it to reabsorption rate at a given filtered load
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The Nephron: The Proximal Tubule Eckert Fig. 14-14 Fluid similar in composition to the plasma enters the PCT from Bowman’s capsule As the filtrate flows along the long PCT, it is heavily modified - PCT is longest segment ; proportional to its role in reabsorption of most of the solute quantity - Most of the water and NaCl and essentially all the organic nutrients are reabsorbed from the lumen Transepithelial transport !
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Epithelia One of the four basic tissue types in the body They are sheets of cells that line all the surface of the body, separating the “outside” from the “inside” Endothelia are a subtype that line blood vessels Distinguished by # of cells in a layer and by shape of the cells Simple vs stratified vs pseudostratified Squamous, cuboidal, columnar Most kidney tubules are a simple cuboidal epithelium Lumen
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Categories of Epithelia
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6 Are divided into the following categories: Exchange
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