Lab Report 5&6 Friedel Crafts Acylation.docx

Lab Report 5&6 Friedel Crafts Acylation.docx - Ty Sides...

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Ty Sides Lab partner- Danae Parman 7/23/17, 3106-302 Umut Ozuguzel, Arpita Singh Experiment 5&6: Friedel-Crafts Acylation: Acetylferrocene and Diacetylferrocene Purpose The purpose of this experiment is to investigate the conditions under which the synthetically important Friedel-Crafts acylation reaction is carried out. This experiment also demonstrates how electrophilic aromatic substitution occurs on an aromatic ring. Reaction and Physical Properties Table Compoun d MW Amount mmol mp( C) bp( C) d n D Aluminum chloride 133.34 150mg 1.12 190 --- --- --- Acetyl chloride 78.50 80 L 1.12 --- 51 1.11 1.3898 Ferrocene 186.04 100mg 0.54 173 --- --- --- Methylene chloride --- 4.0mL --- --- 40 --- --- Safety Aluminum Chloride (Corrosive) Risk Statement: Causes severe skin burns and eye damage Safety Statement: Do not breathe dust/fume/gas/mist/vapours/spray, Wear protective gloves/protective clothing/eye protection/face protection, IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower, IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician, IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Acetyl Chloride (Flammable, Corrosive)
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Risk Statement: Highly Flammable liquid and vapour, Causes severe skin burns and eye damage Safety Statement: Keep away from heat/sparks/open flames/hot surfaces. — No smoking, Do not breathe dust/fume/gas/mist/vapours/spray, Wear protective gloves/protective clothing/eye protection/face protection, IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing, In case of fire: Use for extinction, Store in a well-ventilated place. Keep cool Ferrocene (Flammable, Irritant, Health Hazard, Environmental Hazard) Risk Statement: Flammable solid, Harmful if swallowed, Harmful if inhaled, Suspected of damaging fertility or the unborn child, May cause damage to organs through prolonged or repeated exposure, Very toxic to aquatic life with long lasting effects Methylene Chloride (Irritant, Health Hazard) Risk Statement: Causes skin irritation, Causes serious eye irritation, May cause respiratory irritation, May cause drowsiness or dizziness, Suspected of causing cancer, May cause damage to organs through prolonged or repeated exposure Safety Statement: Do not breathe dust/fume/gas/mist/vapours/spray, Wear protective gloves/protective clothing/eye protection/face protection, IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing Procedure: Lab Period 1 1. Equip a tared 5.0mL conical vial containing a magnetic spin vane with a Claisen head protected by a calcium chloride drying tube and a septum cap.
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