29_Lieb_DNA_Damage

29_Lieb_DNA_Damage - Mutations J Lieb J.D Watson in “The...

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Unformatted text preview: Mutations March 31, 2008 J. Lieb J.D. Watson in “The Double Helix” ROOM CHANGE- Friday, APRIL 04 Manning 209 Heritable phenotypes Phenotypic variation in the population Phenotypic variation affects survival/production of offspring In any system with the following properties: Evolution will occur How does variation arise? How does genetic diversity arise? Mutations • Exposure to mutagens (induced) • Mutagens can replace, alter, or damage a base • “naturally” (spontaneous, background rate) • mistakes in DNA replication, etc Repair • Direct repair • Base Excision Repair • Nucleotide Excision Repair • Homologous Recombination • Non-homologous End Joining Luria and Delbruck experiments Lederberg experiments p. 518-519 Concept: Mutations occur spontaneously Mutations occur before a selection event, not in response to it. ATGCCCGAAGTG TACGGGCTTCAC Point Mutations (Base Substitutions) ATGCCC A AAGTG TACGGG T TTCAC ATGCCC T AAGTG TACGGG A TTCAC transition purine purine pyrimidine pyrimidine transversion purine pyrimidine pyrimidine purine Purines: A and G (two-ring bases) Pyrimidines: C and T (single-ring bases) Mutations are NOT “fixed” until replication Mutations that affect coding sequences AUG CCU CAA UUG UAG met pro gln leu stop AUG C A U CAA UUG UAG met his gln leu stop missense – a single nucleotide substitution that alters a single amino acid; may or may not affect protein function: (table, p. 515) Mutations that affect coding sequences...
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This note was uploaded on 04/22/2009 for the course BIOL 201 taught by Professor Mitchell during the Spring '07 term at UNC.

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29_Lieb_DNA_Damage - Mutations J Lieb J.D Watson in “The...

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