P
OPULATION
G
ENETICS
P
ROBLEM
S
ET
B
IOLOGY
54
F
ALL
2004
Answer all of the following problems.
Show calculations as well as results.
1.
(HWE) Electrophoresis was used to study the gene for phosphoglucose isomerase-2
in the evening primrose
Oenothera biennis
. Two alleles (
A
and
a
) were observed that
affected electrophoretic mobility of the enzyme, and 40 AA, 2 Aa, and 18 aa
genotypes were found among 60 individuals.
a.
Calculate the allele frequencies p = f(A) and q = f(a).
b.
What numbers of the genotypes would be expected if the HW assumption were
met?
c.
Is this population in HWE?
2.
(HWE) Tay-Sachs is a recessive genetic disease that is lethal in early childhood.
Among Jews in the United States, about 1 in 2,800 children are affected. Assuming
random mating among US Jews, what is the frequency of heterozygous carriers?
3.
(HWE) An experimental population of
Drosophila melanogaster
is started with 100
AA
females and 100
aa
males.
a.
What will be the genotype frequencies in the F
1
and F
2
generations, assuming
random mating and that all genotypes reproduce and survive equally well?
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- Spring '07
- MITCHELL
- Genetics, Glucose, Evolution, Population Genetics, aa aa aa, Methicillin
-
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