Exam 1 Lecture Notes - The Life-Span Perspective 2009-01-23...

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The Life-Span Perspective 19:03 The Life-Span Perspective Text: Assumptions of the Life-Span Perspective Ex. Development is a lifelong process Development involves both gain and loss Development is multiply influenced Case Study: Neil from the “Up Series” Interviewed 20 kids when 7 years old (every 7 years) Age 7 Very optimistic (astronaut, carriage driver) Happy and excited Age 14 Slightly less optimistic Seemed normal Age 21 Mentioned his teenage years were not happy Blaming other people for what has happened to him Appears angry Begin to feel pressures from society – need to find out what to do in life Age 28 Lack of self confidence Discusses things he’d like to do but does not. Has stopped blaming others and blames himself. Not complete with given up Age 35 He found a place where he was welcomed Notice interaction between his relationships and his change to staying in one place Growing insights
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Stem Cell 19:03 Stem Cell (SC)
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Stem Cell 19:03 Unspecialized cells Has potential to differentiate into many different cell types Potential Varies: Totipotent SC – Differentiate into any kind of cell that a human needs. Pluripotent SC – Differentiate into almost all kinds of cells. Multipotent SC – Differentiate into a restricted range of specialized cells. Unipotent SC – A cell that duplicates itself, waiting around in order to form a particular  type of cell (ex. spermatagonium, 46 chromosomes in testes   Split to make sperm cells) Self replicates for indefinite periods Non-Controversial SC are – Adult SC Found in bone marrow, cornea, brain, pancreas, etc. Multipotent Ex.  Blood SC’s (red, white. Platelets) Rare Source 1: “Natural” Prenatal Development Totipotent Cells can produce Inner Cell Mass The Primitive Streak
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Stem Cell 19:03 Once implanted: Cells migrate toward the center Dive down into the embryo “Diving” visible as streak Cell movement 3 layers of differentiated cells Blastocyst becomes a gastrula Embryonic SC Potential The fertilized egg: totipotent Inner cell mass cells (embryonic SC’s: pluripotent Differentiate into cells of embryonic layers: Ectoderm, mesoderm, endoderm Source 2: Assisted Reproduction  Origin of SC research From Donated Embryos: Source 3: Somatic Cell Nuclear Transfer (Therapeutic Cloning) Source 4: (As of November 2007) Somatic cells become stem cells without creation of  embryo
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Stem Cell 19:03 1. Viruses carry 4 genes into skin cells 2. Genes reprogram cells, or: “Dedifferentiate” cells Resulting in: 3. Induced Pluripotent cells Why are we studying stem cells? Learning about early development:
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Exam 1 Lecture Notes - The Life-Span Perspective 2009-01-23...

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