{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

Prenatal Devel. II - Teratogens Clastogens I Drugs A Legal...

Info icon This preview shows pages 1–19. Sign up to view the full content.

View Full Document Right Arrow Icon
Teratogens & Clastogens
Image of page 1

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
I. Drugs A. Legal Drugs & Medications
Image of page 2
Percentage of Women taking Drugs during Pregnancy
Image of page 3

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
1. Thalidomide Developed in Germany as an anti-convulsant, then as a tranquilizer 10,000 infants affected with phocomelia, largely in Europe Critical period: 20-36 days after conception
Image of page 4
blocks growth of blood vessels to parts of body undergoing rapid growth may affect DNA; children of thalidomide children have higher rate of limb deformities
Image of page 5

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Image of page 6
Standard Thalidomide symptoms flipperlike arms (phocomelia) & legs heart defects eye, ear, facial deformities kidney & intestinal problems urogenital problems 40% mortality rate 5% of survivors were diagnosed autistic
Image of page 7

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Early exposure affected arms; later exposure affected legs or hands, feet Currently approved by FDA for leprosy, treating growth of tumors in AIDs patients
Image of page 8
2. Antibiotics & Other Medications a. Tetracycline: stains teeth & bones, may affect growth of long bones b. Streptomycin can cause deafness in infants c. Insulin: Fluctuating glucose levels may be teratogenic, but insulin itself is not (see Diabetes, under Diseases)
Image of page 9

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
d. Lithium: congenital heart defects (Ebstein’s anomaly) may result from first trimester exposure (but not a strong teratogen) e. Penicillin & sulfa drugs thought to be safe
Image of page 10
3. Alcohol crosses placenta; equal concentration in fetal blood alcohol metabolism requires oxygen, deprives fetus of oxygen interferes with cell differentiation, migration & growth compounded by nutritional deficits
Image of page 11

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
FAS Symptoms Microencephaly & mental retardation Facial & ear deformities Stunted growth & Low Birth Weight Deformed & webbed fingers and toes Heart and kidney defects Abnormal curvature of the spine Deformed sternum and ribs
Image of page 12
Image of page 13

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
FAS Facial Characteristics
Image of page 14
Normal Brain vs. FAS Brain
Image of page 15

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
increased risk of miscarriage, stillbirths, disturbances in placental functioning risk increases with dosage; 44% of women who drink heavily will have a child with FAS. Even 1-2 drinks/day can result in miscarriage or low birth weight
Image of page 16
Long-term Behavioral Consequences Delayed motor development Delayed language development Seizures Poor Impulse control Hyperactivity Inappropriate behavior
Image of page 17

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Statistics FAS is leading cause of mental retardation in western countries Incidence has increased (perhaps
Image of page 18
Image of page 19
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern