Unformatted text preview: thioester to be more or less readily hydrolyzed by base? 2. How would you synthesize the molecule shown below from the starting material provided? The desired product is a potent antihistamine used in several decongestants. Cl N N Cl N CO 2 H from 3. (Prelim 2, 1999) Propose a practical laboratory synthesis for the molecule shown from bromocyclohexane. Use any other organic reagent with no more than one functional group and four or fewer carbons as the starting material and appropriate inorganic reagents. OH from Br 4. Supply the missing reagents and reaction conditions (a) — (g) for each transformation, some of which require more than one step. In some cases you may have to refer to earlier chapters. OH CO 2 CH 3 O O OH OH O OH O COOH O CO 2 CH 3 CO 2 H O O O O (a) (b) (c) (d) (f) MnO 2 (e)...
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- Fall '06
- GANEM, B
- Isomers, Carboxylic acid, Amide, R R O N R H R thioester O S R R O, base-cataly zed hydrolysis, Th ioesters