Slides Dermatology.pptx - ECTOPARASITIC INFECTIONS ECTOPARASITICIDES Parasites live on surface of host Scabies(Sarcoptes scabiei

Slides Dermatology.pptx - ECTOPARASITIC INFECTIONS...

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DERMATOLOGY
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ACNE
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ACNE Nonpharmacological Gentle cleansing 2-3 times a day Avoid Irritation Vigorous scrubbing or abrasives Oil-based products Dietary measures don’t help
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TREATMENT FOR ACNE Nondrug therapy Cleansing Drug therapy Benzoyl peroxide Antibiotics Topical: clindamycin Oral: tetracycline antibiotics, isotretinoin, hormonal agents Retinoids Tretinoin (Retin-A) Adapalene (Differin)
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Treatment algorithm for acne.
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Copyright © 2015 Wolters Kluwer • All Rights Reserved CHAPTER 34 Figure 34.4
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ACNE - TOPICAL Benzoyl peroxide effective for mild-moderate acne Suppresses growth of P. acnes Effect seen within days No resistance seen Topical tretinoin [Retin-A] effective for inflammatory and non-inflammatory lesions in mild and moderate acne Cornerstone of acne therapy; Great for comedomal acne Reduce inflammation and improve penetration of other topical (thins the stratum corneum) ADR: induce blistering, peeling, crusting, burning, and edema D/C keratolyicc agents prior to using topical tretinoin Apply at night, exposure to the sun increases irritation Topical clindamycin [Cleocin] and erythromycin effective for inflammatory lesions in mild, moderate, or severe acne Suppresses growth of P. acnes Monotherapy quickly leads to resistance Azelaic acid [Finacea] effective for inflammatory and non-inflammatory lesions in mild to moderate acne suppresses growth of P. acnes and by decreasing proliferation of keratinocytes, thereby decreasing the thickness of the stratum corneum. ADR: hypopigmentation
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ORAL DRUGS FOR ACNE Antibiotics Agents of choice Doxycycline (Vibramycin), minocycline (Minocin) Alternatives (resistance is common) Tetracycline (Sumycin), erythromycin (Ery-Tab) Isotretinoin (Accutane) Teratogenic Triglyceride levels must be monitored Hormonal agents
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ACNE - ORAL Antibiotics (doxycycline & minocycline; alternatives: tetracycline & erythromycin due to resistance) PO antibiotics for moderate – severe acne suppress growth of P. acnes and directly suppress inflammation. Benefits takes 3- 6 months Isotretinoin [Accutane, Amnesteen, Claravis] Derivative of vitamin A; treat severe nodulocystic acne vulgaris The drug decreases sebum production, sebaceous gland size, inflammation, and keratinization. Half-life: 10-20 hours ADR: nosebleeds (80%), inflammation of the lips (90%) & eyes (40%), drying/itching of the skin, nose and mouth (80%), depression Pregnancy category X Monitor: Baseline CBC, LFTs, cholesterol/triglycerides, pregnancy
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ECTOPARASITIC INFECTIONS
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ECTOPARASITICIDES Parasites live on surface of host Scabies (Sarcoptes scabiei) Pediculosis—lice (Pediculus humanus) Pubic area (pubis) Head (capitis) Body (corporis)
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Copyright © 2015 Wolters Kluwer • All Rights Reserved CHAPTER 34 Figure 34.6
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THERAPEUTIC OVERVIEW
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