Chapter 3 - Chapter 3 http/courses.cm.utexas.edu/kbrowning/ch369/private/chapter3/chapt 1 of 10 3:45 PM Nucleotides DNA and the Central Dogma NOTE

Info iconThis preview shows pages 1–4. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: Chapter 3 http://courses.cm.utexas.edu/kbrowning/ch369/private/chapter3/chapt... 1 of 10 9/7/07 3:45 PM Nucleotides, DNA and the Central Dogma NOTE: if you cannot see images in the boxes, do not worry about it, they are eye candy, just structures of the molecules in 3D. To view them requires a plug-in called CHIME . Getting it working is sometimes more trouble that it is worth as the plug-in is not compatible with all or newer versions of browsers (firefox) and operating systems (eg mac osX). monomers connected by covalent bond to form polymers DNA and RNA monomers also function in catalysis, energy transfer, hormone signal mediation note that many of the co-substrates have a nucleotide portion--NAD, FAD, etc. purine or pyrimidine ring nitrogen containing, weak base--hence the term "bases" when referring to the nucleotides nitrogens can also ionize at different pHs free bases are rarely found in nature--extremely insoluble double bonds absorb UV--used to quantitate nucleotides/nucleic acids Purines--2 rings; G and A found in RNA and DNA guanine G adenine A Pyrimidines--one ring--C found in RNA and DNA; U in RNA; T in DNA thymine T cytosine C uracil U Many other types of purines and pyrimidines are important in tRNAs and as molecules with biological effects (caffeine and theophylline) Chapter 3 http://courses.cm.utexas.edu/kbrowning/ch369/private/chapter3/chapt... 2 of 10 9/7/07 3:45 PM caffeine--coffee theophylline--tea Nucleosides--contain ribose (RNA-ribonucleosides) or deoxyribose (DNA-deoxyribonucleosides), no phosphate glycosidic bond--C1' carbon of sugar to N-1 of pyrimidines or N9 of purines adenosine-ribo guanosine-ribo cytidine-ribo uridine-ribo thymidine-deoxy Nucleoside Derivatives--mimics that lack the ability to be incorporated into DNA--no 3' OH group used to treat AIDS--inhibits replication of HIV virus used to treat Herpes, shingles, chicken pox AZT--3'-azido-3'-deoxythymidine --Zovirax Nucleotides--OH group of ribose esterified with phosphate monophosphates are dibasic acids with pKa of ~1 and 6 Chapter 3 http://courses.cm.utexas.edu/kbrowning/ch369/private/chapter3/chapt... 2 of 10 9/7/07 3:45 PM caffeine--coffee theophylline--tea Nucleosides--contain ribose (RNA-ribonucleosides) or deoxyribose (DNA-deoxyribonucleosides), no phosphate glycosidic bond--C1' carbon of sugar to N-1 of pyrimidines or N9 of purines adenosine-ribo guanosine-ribo cytidine-ribo uridine-ribo thymidine-deoxy Nucleoside Derivatives--mimics that lack the ability to be incorporated into DNA--no 3' OH group used to treat AIDS--inhibits replication of HIV virus used to treat Herpes, shingles, chicken pox AZT--3'-azido-3'-deoxythymidine --Zovirax Nucleotides--OH group of ribose esterified with phosphate monophosphates are dibasic acids with pKa of ~1 and 6 Chapter 3 http://courses.cm.utexas.edu/kbrowning/ch369/private/chapter3/chapt......
View Full Document

This note was uploaded on 03/19/2008 for the course BIO 416K taught by Professor Findell during the Fall '08 term at University of Texas at Austin.

Page1 / 10

Chapter 3 - Chapter 3 http/courses.cm.utexas.edu/kbrowning/ch369/private/chapter3/chapt 1 of 10 3:45 PM Nucleotides DNA and the Central Dogma NOTE

This preview shows document pages 1 - 4. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online