NURS 6521 week 3.docx - NURS 6521 Advanced Pharmacology...

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NURS 6521 – Advanced Pharmacology Week 3 Case study number 1 Patient AO has a history of obesity with a recent 9 lb. weight gain, newly diagnosed with hypertension and hyperlipidemia. Prescriptions ordered include: Atenolol 12.5 mg daily Doxazosin 8 mg daily Hydralazine 10 mg QID Sertraline 25 mg daily Simvastatin 80 mg daily Pharmacokinetics and pharmacodynamics A healthcare provider that is initiating therapy for hypertension and hyperlipidemia needs to take in consideration a few factors before sending the prescription to the pharmacy. The only known fact about the case is that AO is obese and has gained 9 pounds. To further come up with the appropriate therapy, we have to evaluate the pharmacokinetics and pharmacodynamics of the patient. In general, we have to look at gender (anatomical and physiological differences), metabolism, smoking and drinking status; stress, co-morbidities, and education amongst others (Franconi & Campesi, 2014). According to Ferdinand et al. (2017), hypertension is seen more in blacks (41.2%) compared to non-Hispanic whites (28.0%), and 25.9% Hispanics. As per these authors, the main cause of this disparity is nonadherence to treatment. In return, higher cases of cardiovascular disease, stroke, and kidney disease are also seen in larger numbers among the black community (Franconi & Campesi, 2014). Another important factor to consider is age. As we age and develop other medical issues, the less ability of the liver to metabolize drugs, the
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kidneys are less able to eliminate the drug, which in return can increase side effects (Alomar, 2014). Impact the patient’s recommended drug therapy In regards to AO’s drug therapy, one of the medications ordered is atenolol. What other medical problems does AO have? We need to know this information because there are certain contraindications based on the patient’s history. Certain beta-blockers should not be given to a patient with bradycardia or COPD. Side effects of beta-blockers, in general, include feeling
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