1injuryneoplasia2016spr summer-2.ppt.pptx

1injuryneoplasia2016spr summer-2.ppt.pptx - NUR 2030...

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NUR 2030 PATHOPHYSIOLOGY FOR NURSING PRACTICE Patricia A. Jarosz, PhD, R.N. 374 Cohn Building 577-1798 E-mail: [email protected] All rights reserved. PJarosz, 2016 1
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EVALUATION Four multiple choice exams. The final is cumulative. See syllabus p.2 for grading scale. Academic Integrity (Refer to Wayne State Bulletin) 2
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LEARNING OUTCOMES Define pathophysiology Describe basic concepts common to all diseases Describe mechanisms whereby cells can become injured Explain the changes that occur with atrophy, hypertrophy, hyperplasia, and dysplasia Explain how neoplastic growth is different from normal cell growth Describe carcinogenesis and carcinogens Explain the clinical manifestations associated with cancer 3
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PATHOPHYSIOLOGY study of mechanisms by which disease occurs in living organisms, the responses of the body, and the effects of these diseases on normal function. 4
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THE STUDY OF PATHOPHYSIOLOGY Physiology is the study of body function. Pathophysiology is the study of the body’s response to dysfunction or disease. Disease has been defined as an interruption, cessation, or disorder of a body system or organ structure. 5
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MAJOR ASPECTS OF A DISEASE PROCESS Etiology Pathogenesis Clinical Manifestations Epidemiology 6
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CATEGORIES OF ETIOLOGY Genetic-genes are responsible for some structural or functional defect Congenital-present at birth Acquired-genes and development are normal, but environmental factors cause disease Multifactorial (Complex)-involves a combination of genetic and environmental factors Idiopathic-cause unknown 7
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PATHOGENESIS Development and course of a disease 8
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CLINICAL MANIFESTATIONS Signs-observable phenomena Symptoms-subjective feelings Syndrome-cluster of s/s 9
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CLINICAL COURSE Acute-rapid onset, usually short duration Chronic-longer duration (months or years), onset may be abrupt or insidious 10
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EPIDEMIOLOGY Mortality: deaths associated with a disease Morbidity: describes the effects an illness has on a person’s life Concerned with the incidence, persistence, and long-term consequences of disease Incidence : number of new cases over a time period Prevalence: total number of cases present at a point in time Risk factors : associated conditions 11
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This is a dynamic steady state at which the body maintains itself at a relatively constant composition. A well-functioning cell can maintain homeostasis. Copyright © 2016 F.A. Davis Company HOMEOSTASIS
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Develop adaptive, compensatory changes in an attempt to maintain homeostasis Develop maladaptive changes, which are derangements of structure or function Copyright © 2016 F.A. Davis Company WHEN INJURED, CELLS CAN:
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In circumstances of overwhelming insult, cell injury or cell death can occur. Cell injury can be reversible, but if the injurious agent is persistent or severe enough, cell injury can lead to cell death.
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  • Winter '17
  • Barbara Pieper
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