Section 8 F2017.pdf - NEUR 0010 Section#8 Stephanie Chan...

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NEUR 0010 Section #8 Stephanie Chan + Aidan O’Shea Chemical Control of Brain + Behavior Motivated Behavior
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Logistics Stephanie Chan + Aidan O'Shea NEUR 0010 | F17
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Stephanie Chan + Aidan O'Shea NEUR 0010 | F17 Direct Synaptic Signaling Diffuse Modulatory Systems Neuroendocrine Signaling via the Hypothalamus Networks of the Autonomic NS Patterns of Communication in the Nervous System direct synaptic signaling we covered this in the first part of the course! neuroendocrine signaling via the hypothalamus networks of the autonomic nervous system diffuse modulatory systems 1 2 3 4
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Stephanie Chan + Aidan O'Shea NEUR 0010 | F17 Diffuse Modulatory Systems core neurons small set: just several thousand origin mostly the brainstem nuclei axons widely divergent; each can make up to 100k synapses across the brain NT release diffuse: affects many neurons receptors activated CNS: metabotropic (mostly) remember: metabotropic = G-protein coupled principal NTs norepinephrine (NE) dopamine (DA) acetylcholine (ACh) serotonin (SE/5-HT) Diffuse Modulatory Systems: An Overview diffuse modulatory systems coordinate the activation states of groups of neurons encompassing broad, disparate regions of the brain
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Stephanie Chan + Aidan O'Shea NEUR 0010 | F17 Diffuse Modulatory Systems The Noradrenergic System if a neuron produces norepinephrine (NE), it is said to be noradrenergic origin: locus coeruleus projections: throughout cortex, thalamus, and cerebellum function: generally excitatory, increasing responsiveness of brain cells activity: especially active during attentive tasks + wakefulness NE is also used as an NT in the PNS neocortex hypothalamus temporal lobe locus coeruleus (literally, ”blue place”) thalamus to spinal cord + beyond cerebellum
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Stephanie Chan + Aidan O'Shea NEUR 0010 | F17 Diffuse Modulatory Systems The Dopaminergic System if a neuron produces dopamine (DA), it is said to be dopaminergic origin: chiefly, the substantia nigra. degeneration of SN in Parkinson’s can devastate this system. however, DA neurons are found throughout the CNS. projections: (1) substantia nigra striatum (2) ventral tegmental area prefrontal cortex, nucleus accumbens + limbic system function: SN loop important for initiating movement. VTA loop is important for the brain’s central reward mechanism ventral tegmental area striatum frontal lobe substantia nigra
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Stephanie Chan + Aidan O'Shea NEUR 0010 | F17 Diffuse Modulatory Systems The Serotonergic System if a neuron produces serotonin (SE/5-HT), it is said to be serotonergic origin: raphe nuclei projections: predominantly forebrain function: acts with the locus coeruleus as the reticular activation system to modulate sleep/wake cycles and activate and deactivate the forebrain involved in control of mood: selective serotonin reuptake inhibitors (SSRIs) such as Prozac or Zoloft are efficacious in treating clinical depression neocortex hypothalamus temporal lobe thalamus to spinal cord + beyond cerebellum raphe nuclei basal ganglia
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Stephanie Chan + Aidan O'Shea NEUR 0010 | F17 Diffuse Modulatory Systems The Cholinergic System thalamus neocortex
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