key_exam3-vr2 - CH 369 Exam Mar. 6. 2008 Version 2 Name:...

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Unformatted text preview: CH 369 Exam Mar. 6. 2008 Version 2 Name: UTEID: Instructions: 1. Please bubble in your name, UTEID and the version number of your exam on the scantron sheet. 2. Answers 1-40 must be marked on the scantron sheet. Only the scantron sheet will be graded. 3. Questions 41-46 should be answered on this exam. 4. All requests for addition error or regrading must be made within 1week of receiving your exam. No exceptions. 5. Addition errors and regrading questions 41-46 should be taken to the TA. Any exam turned in for regrade will be completely regarded. Section Points I 10 II 60 III 30 Total 100 Section I (1pt each) (Questions 1 - 4) Indicate the place where the following occur in: 1. Glycolysis a. cytosol b. mitochondria intermembrane space c. mitochondria matrix 2. Pentose phosphate pathway a. cytosol b. mitochondria intermembrane space c. mitochondria matrix 3. Citric acid cycle a. cytosol b. mitochondria intermembrane space c. mitochondria matrix 4. ATP synthesis by complex V in oxidative phosphorylation system a. cytosol b. mitochondria intermembrane space c. mitochondria matix (Questions 5 - 7) Predict the effect of each of the following on the pace of glycolysis : 5. Increasing the concentration of ATP a. increased b. decreased 6. Loss of the phosphatase domain of the enzyme that controls the level of fructose 2,6- bisphosphate (Hint: In this case, the concentration of fructose 2,6-bisphosphate would be increased.) a. increased b. decreased 7. Loss of the binding site for fructose 1,6-bisphosphate in pyruvate kinase in yeast. (In yeast, fructose-1,6-bisphosphate activates pyruvate kinase at an allosteric site.) a. increased b. decreased (Questions 8 9) For each of the conditions below, predict the state of oxidation of electron carriers such as ubiquinone, cytochromes b, c and c1 in oxidative phosphorylation system 8. Abundant NADH, but O 2 exhausted a. all carriers reduced b. all carriers oxidized 9. Abundant O 2 , but NADH exhausted a. all carriers reduced b. all carriers oxidized 10.NADH is transported via transporters directly to the mitochondria to transfer electron to ubiquinone a. True b. False Section II (2pt each) 11. If an individual has a defect in complex-I (involved in oxidative phosphorylation), which prevents it from binding NADH, what is the effect on citric acid cycle? a. Decreased flux b. Increased flux c. No effect d. Increased tendency towards anaplerotic reactions e. B and D 12. Malonate is a competitive inhibitor of succinate dehydrogenase. What citric acid cycle intermediates accumulate if malonate is present in a preparation of isolated mitochondria?...
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key_exam3-vr2 - CH 369 Exam Mar. 6. 2008 Version 2 Name:...

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