Examination of “Panacetin”.docx

Examination of “Panacetin”.docx - Experiment 2 Analysis...

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Experiment 2 Analysis and Separating Components of “Panacetin” Organic Chemistry I Lab Date: 9/15/2017 Introduction/ Question
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Drug caplets contain a variety of different substances combined into an easily swallowed pill form. By applying different chemical treatments to these medicines, they can be separated into their component chemicals. This experiment examines the hypothetical drug “Panacetin” and asks to determine the percentage compositions of sucrose, aspirin, and unknown contained within the drug. Hypothesis Panacetin is labeled to have a concentration of 10% sucrose, 40% Aspirin and 50% unknown. If the 0.800g sample of Panacetin is efficiently separated into its chemical components then we can expect a percent recovery around 80% which will yield 0.064g of sucrose [0.8g Panacetin * 80% recovery * 10% composition sucrose], 0.266g of aspirin [0.8g Panacetin * 80% recovery* 40% composition aspirin] and .320g of unknown [.800g Panacetin * 80% recovery * 50% composition unknown]. Materials Centrifuge “Panacetin” 5% Sodium bicarbonate(14mL) Sodium acetylsalicylate Dichloromethane Scale 3 Test tubes and Stoppers 2 small beakers Stirring Rod Ice 4 dram screw cap vial Filter paper Pipettes Scoopula Vacuum filtration setup Litmus paper Procedure
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We can summarize the procedure as following order: Panacetin + dichloromethane ( CH 2 Cl 2 ) → Sucrose + unknown Unknown + Sodium bicarbonate (Na 2 CO 3 ) → dichloromethane layer (organic) + aqueous layer Aqueous layer + Hydrochloric Acid (HCl) → Aspirin We measured 0.8g of panacetin and added dichloromethane to get a mixture, and centrifuged our solution. The result was sucrose that precipitated and we were able to separate it by vacuum filtration from our solution, and the remaining liquid was used for the next step. By adding sodium bicarbonate two layers of liquid was generated. The top was the aqueous layer and the bottom was the dichloromethane which was our organic layer containing unknown that we separated them in 2 different tubes. Then we added 6M hydrochloric acid to the top layer reach a pH of 2 or lower which we used an indicator to reach that point. We cooled down the mixture in ice bath and collect the precipitated product which was aspirin by using vacuum filtration. The bottom layer of dichloromethane will be used to identify the unknown constituents of “Panacetin” by the process of recrystallization and melting-point measurement in the next lab session.
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