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Study _guide_2006_Fall

Study _guide_2006_Fall - Study guide for Chem 430 Final...

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Study guide for Chem 430 Final Exam Life and water 1. types of biomolecules, structure of water, H-bonding potential, water as a solvent and effect on structure/function of biomolecules. Chem. 21 thermodynamics. Amino Acids 1. general acid base properties (pI, pK, etc.) 2. general characteristics of R-grps; know who is polar, nonpolar, ect. (1,3-letter codes, chemistry, charge at given pH) 3. the peptide bond – general nature and chemistry, net charge of a given polypep. Proteins-primary structure 1. Protein sequencing – use of endopeptidases 2. general approaches to protein purification based on amino acid composition 3-D structure of proteins 1. primary, secondary, and tertiary structure – general characteristics and chemistry 2. forces involved in formation and stabilization of above structures 3. Protein folding and renaturation – how? Why? Anfinsen’s expt. Protein function 1. Structure of myoglobin. Substrate binding characteristics. Shape of Mb binding curve-implications 2. Structure of hemoblobin. Substrate binding characteristics. Shape of Hb binding curve-implications. T R transition upon S binding – concept and structural implications 3. effect of single amino acid mutation in Hb and physiological effect Carbohydrates 1. Classification of carbohydrates (broad classes) and general chemical characteristics 2. covalently joining monosaccharides, the glycosidic bond, anomers, epimers 3. carbohydrate derivatives, proteoglycans, glycoproteins, importance of carbohydrates in cell-cell recognition. 4. glycogen vs. cellulose Enzyme catalysis 1. general properties of enzymes – S binding, nomenclature 2. catalytic mechanisms – serine proteases as an example
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3. activation energy and the reaction coordinate – effect of enzymes?
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