(10) Revised Special Baby.ppt - NEONATAL JAUNDICE Dr Leow Poy Lee Pakar Pediatrik Hospital Kuala Pilah NEONATAL JAUNDICE Common phenomenon in

(10) Revised Special Baby.ppt - NEONATAL JAUNDICE Dr Leow...

This preview shows page 1 - 7 out of 31 pages.

NEONATAL NEONATAL JAUNDICE JAUNDICE Dr. Leow Poy Lee Pakar Pediatrik Hospital Kuala Pilah
Image of page 1
NEONATAL JAUNDICE Common phenomenon in neonates (Incidence up to 40-50% Asians, 10% Caucasians – S’pore study) Increased indirect bilirubin (> common) and/or direct bilirubin C/b excessive RBC destruction or reduced ability of liver to excrete
Image of page 2
Image of page 3
Aetiology of NNJ 1. Physiological jaundice 2. Haemolytic : ABO incomp, Rh incomp, G6PD def, pyruvate kinase def, Hereditary spherocytosis/elliptocytocytosis 3. Polycythaemia, Haematoma, Bruises 4. Infection: Septicaemia, UTI, Intrauterine infn 5. Metabolic disease: Hypothyroidism, Galactosaemia, L-1antitrypsin def., Crigler- Najjar Syn, Dubin-Johnson and Rotor syn 6. Obstructive jaundice: Biliary atresia, choledochal cyst, Neonatal hepatitis syn. 7. Breastmilk jaundice
Image of page 4
Physiological Jaundice Common in first week of life ( start D2-3, peak at D4-5, resolve by D7-8) Due to: Increased bilirubin load (larger RBC volume,shorter RBCs life span,increased enterohepatic circulation) Reduced uptake of bilirubin by the liver Reduced conjugation TSB usu. < 12-15mg% Aggravated by poor caloric intake, dehydration, GIT stasis, prematurity
Image of page 5
Haemolytic Jaundice Early-onset jaundice (within 24 hrs of life), rapid rise. Rhesus incomp . 15% Caucasian women are Rhesus negative, Indians 5%, Chinese and Malay 1% Sensitised by Rh positive blood (previous pregnancy,bld transfusion.) First baby usu. alright, subsequent ones increased severity. May result in Hydrops foetalis.
Image of page 6
Image of page 7

You've reached the end of your free preview.

Want to read all 31 pages?

  • Fall '15
  • MrRosdi

  • Left Quote Icon

    Student Picture

  • Left Quote Icon

    Student Picture

  • Left Quote Icon

    Student Picture

Stuck? We have tutors online 24/7 who can help you get unstuck.
A+ icon
Ask Expert Tutors You can ask You can ask You can ask (will expire )
Answers in as fast as 15 minutes