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N5315 Advanced PathophysiologyFluid and ElectrolytesModule Core Concept and Objectives with Advanced OrganizersFluid and Electrolytes1. Analyze the pathologic consequences of fluid volume disorders on the mechanisms of fluid homeostasis.a. Explain the three main fluid compartments and describe how fluid shifts between the compartments and the implications for clinical practice.Fluid CompartmentsDefinitionPattern of Fluid ShiftsClinical ImplicationsIntravascularThe intravascular space contains 20% of the total body water.Both in and out of the interstitial and intracellular spacesHypertonicIV solution, when administered, will increase the solute concentration in theintravascular space. Volume overloadVenous retentionIncreased venous pressure edemaInterstitialThe interstitial space contains 20% of the total body water.Due to the increase in solute concentration in theintravascular space, water will flow via osmosis from the extracellular space to the intravascular space. This will leave the extravascular space with a higher concentration of solutes than the intracellular space.Fluid will shift from intracellular into the extracellular space.
b. Analyze the principles of fluid balance and describe the implications for clinical practice.