N5315 Advanced Pathophysiology Altered Cellular Function and Cancer Module Core Concepts and Objectives with Advanced Organizers Cellular Physiology 1.Analyze the steps of the action potential. 2. Discuss how the action potential is altered by calcium and sodium imbalances and the clinical significance · Na has a greater concentration in the ECF. When a neuron is excited by a stimulus, the stimulus-gated Na+ channels open allowing Na+ to move intracellularly. This moves the resting membrane potential of -70mV more towards 0. Once the threshold potential is reached (-59mV) the voltage gated Na+ channels open allowing for more Na+ to move into the cell and complete the depolarization to a maximum of +30mV. If the depolarization does 1
not reach a minimum of -59mV (threshold potential) the voltage gated Na+ channels will not open and the cell will simply repolarize to -70mV without generating an action potential.
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- Fall '15