2017Bio3058exam1(1).pdf - STEIN IN-TERM EXAM BIOLOGY 3058...

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STEIN IN-TERM EXAM -- BIOLOGY 3058 -- FEBRUARY 16, 2017 -- PAGE 1 of 9 STEIN IN-TERM EXAM -- BIOLOGY 3058 -- FEBRUARY 16, 2017 -- PAGE 1 of 9 There are 25 questions in this Biology 3058 exam. All questions are "A, B, C, D, E, F, G, H" questions worth one point each. There is a total of 25 points in this exam. Fill in your answers on the separate answer sheet . The format for this exam is: Fill in A if A is the only correct answer. Fill in B if B is the only correct answer. Fill in C if C is the only correct answer. Fill in D if both A and B are correct (and C is NOT correct). Fill in E if both A and C are correct (and B is NOT correct). Fill in F if both B and C are correct (and A is NOT correct). Fill in G if A and B and C are all correct. Fill in H if none of the above is correct (A is NOT correct, B is NOT correct, and C is NOT correct). ONLY MARK ONE LETTER PER QUESTION. You may keep the question sheets. Use a dark (black or blue) pencil or dark (black or blue) pen to fill in the answers. DO NOT USE A RED PEN; DO NOT USE A RED PENCIL. 1. A new drug named ANTAG-CaSR has been developed that is an antagonist at calcium-binding sites of CaSRs (Calcium-Sensing Receptors) in the plasma membranes of parathyroid gland cells. Healthy Person P receives regular doses of ANTAG-CaSR as part of a clinical trial. When ANTAG-CaSR levels in the extracellular spaces surrounding parathyroid gland cells increase in Healthy Person P, then there is an increase in the amount of ANTAG-CaSR bound to binding sites on CaSRs in parathyroid gland cells. This increase in the amount of ANTAG-CaSR bound to binding sites on CaSRs in parathyroid leads to A. a decrease in the levels of parathyroid hormone in the blood plasma. B. a decrease in the amount of calcium excreted in the urine. C. a decrease in the amount of 1,25-dihydroxyvitamin D binding to Vitamin D Receptors (VDRs) in the nucleus of cells in the intestine. D. A and B. E. A and C. F. B and C. G. A, B, and C. H. None of the above. 2. Patient X has blood plasma levels of Parathyroid Hormone (PTH) that are always very high due to a tumor consisting of Parathyroid Gland cells that continuously secrete high levels of PTH into the blood plasma. Which of the following drugs will help relieve some of the problems for Patient X? A. Drug A that is an agonist of the Parathyroid Hormone Receptor (PTHR). B. Drug B that is an antagonist of the calcium-binding site of the Calcium-Sensing Receptor (CaSR). C. Drug C is a lipid-soluble molecule that is an agonist of the Vitamin D Receptor (VDR). D. A and B. E. A and C. F. B and C. G. A, B, and C. H. None of the above.
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STEIN IN-TERM EXAM -- BIOLOGY 3058 -- FEBRUARY 16, 2017 -- PAGE 2 of 9 STEIN IN-TERM EXAM -- BIOLOGY 3058 -- FEBRUARY 16, 2017 -- PAGE 2 of 9 3. Which of the following serves as an actuating signal, or as part of an actuating signal, in a negative feedback system?
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