NURS 6501 week 6 assign.docx - Running head ASTHMA 1 Asthma Fidelis Orji Walden University NURS 6501 Advanced Pathophysiology January 1 2018 Week 6

NURS 6501 week 6 assign.docx - Running head ASTHMA 1 Asthma...

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Running head: ASTHMA 1 Asthma Fidelis Orji Walden University NURS 6501: Advanced Pathophysiology January 1, 2018 Week 6 Assignment
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ASTHMA 2 Asthma Asthma is a disease that affects over 30 million Americans, and is mostly diagnosed during childhood to (Huether & McCance, 2017). When Asthma is not properly diagnosed or diagnosed late, it could lead to chronic changes in the airways. Asthma is a chronic disease and can show up at any age and is not gender specific (National Asthma Education, 2007). According to Huether and McCance (2017), asthma can present itself in children when exposed to high level of allergens. Smoking, exposure to allergens, air pollution and re-occurring respiratory infection all put an individual at risk for asthma. When an individual inhales irritants, it could create some permanent changes in the airways. Pathophysiology When the bronchial mucosa is exposed to allergens, it stimulates the dendritic cells, and this pushes antigen to the T-helper cells. The T-helper cells release both cytokines and interleukins that stimulates plasma cells and eosinophils. Thus, leading to obstruction of the airways (Huether & McCance, 2017). The plasma cells create IgE, and it connects to the mast cells, and it causes degranulation due to the discharge of inflammatory mediators like histamine and bradykinins. Inflammatory mediators lead to mucosal edema, bronchospasm, and vasodilations which contribute to narrowing the airways. Asthma manifest differently in people, and they can range from an acute exacerbation to a severe attack (Hammer & McPhee, 2014). Wheezing is a classic sign of asthma, and this is
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