protein structure outline test one

protein structure outline test one - Proteins: Structure...

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Proteins: Structure and Function: The Shape and Structure of Proteins: Primary structure: amino acid sequence: Experiments that demonstrate that the primary structure (sequence) of a protein determines its final conformation include the in vitro folding of purified proteins that are denatured, and the in vitro folding of chemically synthesized proteins.
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Secondary structure: stretches of polypeptide chains that form alpha helices and beta sheets: The 2-D shape of a protein is specified by its amino acid sequence. Charged and uncharged or polar and nonpolar amino acid side chains extending off of polypeptide chain interact with one another to form secondary structure. There are two main types. Alpha-helix: The a-helix is so common because it does not depend on the side chains for stability, instead hydrogen bonds between C=O and N-H in the polypeptide backbone within the helix hold the structure together. Short regions of alpha-helix are especially abundant in proteins located in cell membranes such as transport proteins and receptors. Beta-sheet: The b-sheet is so common because it does not depend on the side chains for stability, instead hydrogen bonds between C=O and N-H in the polypeptide backbone of different b-sheets hold the structure together. The core of many proteins contains extensive regions of beta-sheets. Both parallel (sheets from neighboring polypeptide chains that run in same direction) and antiparallel (chains running in opposite direction of that of its immediate neighbor) produce very rigid structures held together by hydrogen bonds that connect peptide bonds in neighboring chains.
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Tertiary Structure: The full 3D organization of a polypeptide chain: The primary sequence of a protein (its amino acid sequence) contains the complete instruction that determine its 3D conformation. The order of the amino acids in a protein’s chain determines its 3D structure. This final folded structure or conformation is generally the one in which the free energy is minimized. Although proteins can be
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This note was uploaded on 03/20/2008 for the course CBIO 3400 taught by Professor Shen,kipreos during the Spring '08 term at University of Georgia Athens.

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protein structure outline test one - Proteins: Structure...

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