Epi 202 Lab 4.docx - Epi 202 Lab 4 The data from an incidence density-sampled case control study of the association between caffeine intake and

# Epi 202 Lab 4.docx - Epi 202 Lab 4 The data from an...

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Epi 202 Lab 4 The data from an incidence density-sampled case control study of the association between caffeine intake and Parkinson’s disease is below. The exposure of interest is caffeine intake (high vs. low) and the outcome is Parkinson’s disease. Cases were appropriately matched to control (1:1 matching) by age and smoking status. Pair Case Control Pair Case Control 1 + - 11 + - 2 + + 12 - - 3 - + 13 - + 4 - - 14 - + 5 - + 15 - - 6 + - 16 + - 7 - - 17 - + 8 - + 18 - + 9 - + 19 + + 10 + + 20 + - 1. Make a 2x2 table for the matched case-control data Case - Control Exposed Unexposed Total Exposed 3 8 11 Unexposed 5 4 9 Total 8 12 20 2. Calculate and Interpret the odds ratio for the association of coffee intake (high vs. low) and Parkinson’s disease, accounting for the matching factors. ^ ¿ = f 10 f 01 = 5 8 = 0.625 The odds of Parkinson’s disease for individuals with high caffeine intake is 0.625 times the odds of Parkinson’s disease for individuals with low caffeine intake, after accounting for the matching factors (smoking status and age), assuming no residual confounding by smoking status and age, no other unmeasured confounding, no selection bias and no information bias.

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