5_Blood_4_immuno_1.pdf - BLOOD 4/IMMUNOLOGY 1 Blood typing...

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9/11/2017 1 B LOOD 4 /I MMUNOLOGY 1 Blood typing and transfusions Intro to Immunology You’re losing blood. I have plenty. Take some of mine! T RANSFUSIONS Packed red cells (plasma and WBCs removed) transfused to restore oxygen-carrying capacity Transfusion of incompatible blood can be fatal
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9/11/2017 2 H UMAN B LOOD G ROUPS RBC membranes bear glycoprotein antigens Promoters of agglutination; called agglutinogens Presence or absence of each antigen is used to classify blood cells into different groups agglutination A B B A N AMED BASED ON A NTIGEN ( AGGLUTINOGENS ) Type A Type B AB O A B B A = “A” Anti gen (agglutinogens ) A A A ANTI B ANTI B ANTI B ANTI B= anti-B antibodies (agglutinins)
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9/11/2017 3 A = “A” Anti gen (agglutinogens ) A A ANTI B ANTI B ANTI B ANTI B= anti-B antibodies (agglutinins) B B A = “A” Anti gen (agglutinogens ) A B A ANTI B ANTI B ANTI B= anti-B antibodies (agglutinins) B ANTI B hemolysis Agglutinins binds to agglutinogens leading to agglutination Duke’s Cameron Stadium is the blood You are RBC and your sign in the antigen Duke supporters are the antibody
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