Chapter_21(1).pptx - Chapter 21 Antidepressant Agents Copyright 2013 Wolters Kluwer Health | Lippincott Williams Wilkins Affective Disorder vs

Chapter_21(1).pptx - Chapter 21 Antidepressant Agents...

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Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Chapter 21: Antidepressant Agents
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Copyright © 2017 Wolters Kluwer • All Rights ReservedAffective Disorder vs. DepressionAffective Disorder vs. DepressionAffective DisorderA person’s mood goes far beyond the usual, normal “ups and downs”DepressionSevere and long-lasting feelings of sadness lasting beyond period identified with precipitating event
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Copyright © 2017 Wolters Kluwer • All Rights ReservedSigns and Symptoms of DepressionSigns and Symptoms of DepressionLow energy levelSleep disturbancesLack of appetiteLimited libidoInability to perform activities of daily livingOverwhelming feelings of sadness, despair, hopelessness, and disorganization
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Copyright © 2017 Wolters Kluwer • All Rights ReservedBiogenic Amine Theory of DepressionBiogenic Amine Theory of DepressionDepression results from a deficiency of norepinephrine (NE), dopamine, or serotonin (5HT)Monoamine oxidase (MAO) may break them down to be recycled or restored in the neuronRapid fire of the neurons may lead to their depletionThe number or sensitivity of postsynaptic receptors may increase, depleting neurotransmitter levels
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Copyright © 2017 Wolters Kluwer • All Rights ReservedActions of Antidepressant TherapyActions of Antidepressant TherapyInhibit the effects of MAO, leading to increased NE or 5HT in the synaptic cleftBlock reuptake by the releasing nerve, leading to increased neurotransmitter levels in the synaptic cleftRegulate receptor sites and breakdown of neurotransmitters, leading to an accumulation of neurotransmitters in the synaptic cleft
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Copyright © 2017 Wolters Kluwer • All Rights ReservedClassifications of AntidepressantsClassifications of AntidepressantsTricyclic Antidepressants (TCAs)MAO Inhibitors (MAOIs)Selective Serotonin Reuptake Inhibitors (SSRIs)
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Copyright © 2017 Wolters Kluwer • All Rights ReservedSites of Action for the AntidepressantsSites of Action for the Antidepressants
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Copyright © 2017 Wolters Kluwer • All Rights ReservedTricyclic Antidepressants Tricyclic Antidepressants ActionsReduce the reuptake of 5HT and NE into nervesUseAll TCAs are similar
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