11. Immunity Hypersensitivity, HIV.rtf

11. Immunity Hypersensitivity, HIV.rtf - Immunity...

This preview shows page 1 - 5 out of 36 pages.

Immunity Lymphocytes T lymphocytes 70-80% circulating lymphocytes Responsible for immunity to intracellular viruses, tumor cells, and fungi NK Cells Natural Killer Cells Significant role in immune surveillance for malignant cell changes Lymphocytes-Fight Infection B lymphocytes the “big guns” measured by lab values. Are plasma lymphocytes and produce antibodies Immune globins: IgG, IgA, IgM, IgD, and IgE IgG -responsible for secondary immune response Will present with frequent infection with IgG deficientcy These pts often have asthma (which is rooted to autoimmune deficiency) Teaching for these people includes prevention of infection (hand washing, large crowds, immunizations (flu/pneumonia/etc)) IgA -lines nose, gut, and fights infections Likely present with GI disturbances; sinus infections; asthma
Image of page 1
IgM -primary immune response IgE -causes symptoms of allergic reaction (likely high in anaphylaxis rxns) Hypersensitivity Reactions Immune system becomes over reactive to foreign antigens 4 types of hypersensitivity reactions Type 1 IgE reaction (Humoral) Anaphlactic reactions occurring in susceptible people who are highly sensitized to specific allergens IgE antibodies attach to mast cells and basophils, triggering destruction of cell Histamine and lots of other stuff are released into system, causing clinical allergy response Increased vascular permeability, vasodilation, hypotension, increased secretion of mucous, itching… Anaphlactic reactions occurring in susceptible people who are highly sensitized to specific allergens IgE antibodies attach to mast cells and basophils, triggering destruction of cell Histamine and lots of other stuff are released into system, causing clinical allergy response Increased vascular permeability, vasodilation, hypotension, increased secretion of mucous, itching…
Image of page 2
Clinical manifestations depend on if reaction is localized or systemic Wheal and flare reaction ( localized rxn ) Pale wheal contains edematous fluid and red flare is from hyperemia Mosquito bite Anaphlaxis ( systemic rxn ) Usually occurs within minutes Bronchial constriction, airway collapse, and vascular collapse Type 1---Atopic Reactions Affects 20% of population Sensitive to environmental allergens Allergic rhinitis, asthma, atopic dermatitis, angioedema, and uticaria What is angioedema and what common class of medication can cause it? Swelling of face/lips (Ace I’s ) Asthma Type 2 Cytotoxic and Cytolytic Reactions Type 2 Cytotoxic and Cytolytic Reactions Direct binding of IgG or Ig M to antigen on cell surface
Image of page 3
Cellular tissue ultimately destroyed Cells usually destroyed are RBC’s, platelets, leukocytes ABO incompatibility transfusion reactions (hemolytic) Type 3 Immune Complex Reactions Secondary to antigen-antibody complexes Antigens bind with IgG and IgM to form complexes too small to be removed by phagocytosis
Image of page 4

Want to read all 36 pages?

Image of page 5

Want to read all 36 pages?

You've reached the end of your free preview.

Want to read all 36 pages?

  • Spring '12

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern