Musculoskeletal Microbiology

Musculoskeletal Microbiology - Term Definition...

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Term: Osteomyelitis Definition: An infection of the bone characterized by inflammatory destruction, necrosis, and inhibition of new bone formation. Maybe acute or chronic. Term: Hematogenous osteomyelitis Definition: Blood-borne. Most common in children. Common in long bones and vertebrae. ESR and C reactive protein levels elevated. Term: Osteomyelitis secondary to Contiguous infection Definition: Bacteria introduced by trauma. Increasing pain accompanied by mild fever. Imaging is not usually diagnostic. Most commonly poly microbial. Staphylococcus aureus, Streptococcus pyogenes, enterococcus, Pseudomonas in chronic cases. Term: Diabetic foot infections Definition: Osteomyelitis secondary due to vascular insufficiency. Pain and fatigue in the area of previously traumatized skin but may have no pain due to advanced neuropathy. Poly microbial or single bacterial cost. Seen on radiograph. Usually Staphylococcus aureus.
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Term: Crepitus Definition: Crackling or grading feeling or sound in joints indicating an infection with anaerobes or Enterobacteriaceae Term: Staphylococcus aureus Definition: Gram-positive cocci. Catalase positive. Co positive. Virulence factor is protein A which binds to constant region of IgG Ab. preventing Ag binding. Capsule to evade phagocytosis. Enterotoxin. Antibiotic resistance due to beta lactamase enzyme & penicillin binding protein. Term: Strep agalactiae Definition: Osteomyelitis in infants. Gram-positive cocci in chains. Beta-hemolytic. Catalase negative. Lancefield system. Hydrolyzes hippurate. Virulence factors; anti-phagocytic. Bacitracin resistant. Term: Streptococcus pyogenes Definition: Osteomyelitis and children. Beta-hemolytic. Normal flora of Respiratory tract. Capsule
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Term: Viridans Definition: Group of streptococci but not a species. Alphahemolytic. Usually commensals Term: Streptococci pneumoniae Definition: Diplococci or short chains.
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