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VST202 - Clinical

VST202 - Clinical - Term Definition What is hemostasis the...

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Term: What is hemostasis? Definition: the stoppage of blood flow, maintain blood w/i the vascular system, the arrest of bleeding from an injured blood vessel Term: What are the 3 functional components to maintain hemostasis? Definition: 1. vascular 2. platelets (primary hemostasis) - for minor breaks in vessel endothelium 3. coagulation (secondary hemostasis) - for larger breeches in vessel integrity Term: What does the vascular component do? Definition: reduces the blood flow Term: How does the vascular component reduce the blood flow? Definition: by local vasoconstriction and compression of injured vessels by blood extravasated into surrounding tissues i.e. oral hematoma, bleeding will stop when out of room
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Term: What are the components of platelets? Definition: hemostatic plugs, platelets also release factors to: augment vasoconstriction, initiate vessel wall repair Term: What is coagulation? Definition: sequential cascade of enzymatic reactions, forms fibrin mesh to stabilize platelet plug. Fibrin clot, stops bleeding Term: Which factor is probably made in the liver, but no one knows for sure? Definition: factor 8, all other clotting factors made from liver. Term: Which clotting factor is missing from the 1-13? Definition: number 6, b/c someone named it twice by accident Term: What ion is clotting factor 4 made of? Definition: calcium ion
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Term: Why is clotting factor 4 the most important clotting factor? Definition: it is involved in every pathway, most anticoagulants work by combining calcium Term: What is part of the intrinsic pathway? Definition: PK HMWK 12 6 9 8 which leads to the common pathway and APIT at 5, ACT at 2 Term: What is part of the extrinsic pathway system? Definition: Tissue Factor 3 and 7 which leads to the common pathway and OSPT at 5 Term: What factors are in the common pathway?
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