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Hypnotics

Hypnotics - Term Definition Benzodiazepines MOA target GABA...

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Term: Benzodiazepines Definition: MOA: target GABA receptors inhibiting action potential and thus providing a calming/sedating effect. Alpha-1 GABAa receptors = sedation/anticonvulsant/amnesia Term: Flurazepam (Dalmane) Definition: Benzodiazepine Long half-life may cause daytime drowsiness Term: Temazepam (Restoril) Definition: Benzodiazepine Help stay asleep Term: Triazolam (Halcion) Definition: Benzodiazepine Short half-life. Help get to sleep
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Term: Benzodiazepine receptor agonist Definition: MOA: bind to BZ1 receptor producing benzodiazepine-like result of action potential inhibition and sedation Term: Zolpidem (Ambien) Definition: Benzodiazepine receptor agonist Regular release: Onset = 7-27 min. duration = 6-8 hr Controlled release: onset = 7-27 min. duration = 8-9 hr Approved for up to three weeks Term: Zaleplon (Sonata) Definition: Benzodiazepine receptor agonist Onset: 30 minutes. Duration: 6 hours Approved for up to three weeks of use Term: Antihistamines Definition: MOA: Blocks histamine binding
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