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Hematology

Hematology - Term Definition When is physiologic Hgb nadir...

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Term: When is physiologic Hgb nadir? Definition: 2-3 months (8-10 weeks) Term: When should you follow up what looks like physiologic anemia? Definition: only in cardio compromise or premie Term: what causes physiologic nadir? Definition: low EPO production Term: normal MCV for babies? adults? Definition: 70-90, 80-100 Term: Most common causes of microcytic anemia? Definition: thalassemia, iron deficiency, lead poisoning, anemia of chronic disease
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Term: What is genotype in beta thal minor or thal trait? Definition: one defective beta globin gene Term: What is genotype in beta thal intermedia? Definition: 2 abnormal beta genes Term: presentation of beta thal intermedia? Definition: mild anemia, may need transfusion after illness Term: Other name for beta thal major? Definition: Cooley's anemia Term: presentation of beta thal major? Definition: severe microcytic anemia requiring transfusion
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Term: What gives Hgb electro of low A1, high A2, and high F? Definition: beta thal Term: What does pairing of alpha and beta globin make? alpha and delta? alpha and gamm? Definition: A1, A2, and F Term: Typical presentation of beta thal major? Definition: Greek kid, hepatosplenomegaly, increased A2 and F, XR with thickened bone and "hair on end" appearance of skull Term: what causes hair on end appearance of skull in beta thal major? Definition: extra medullary hematopoiesis Term: long term complications of chronic transfusion therapy? Definition: cholelithiasis, hemosiderosis
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Term: Where does hemosiderosis from chronic transfusions affect? Definition: liver, heart, and pancreas Term: What are people with one abnormal alpha hgb gene called? two? three? 4? Definition: silent carriers, alpha thal trait, Hgh H or alpha thal major, hydrops Term: two abnormal tetramers formed in Hgb H disease? Definition: Barts (4 gammas), Hgb H (4 betas) Term: when does risk for iron deficiency present itself? Definition: after 6 months, especially in breast fed babies Term: Patient with illness presents with microcytic anemia, given iron, did iron help? Definition: No crit would rebound on its own
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Term: when is parenteral iron used? Definition: only when kid cannot take it orally or in very extreme social circumstance Term: What is the RDW for iron deficiency anemia? thalassemia? Definition: high for I in iron and high. Low for the l in thaLassemia and low Term: what is TIBC in anemia of chronic disease? Definition: low, plenty of iron just no energy to pick it up. Term: What is serum ferritin in anemia of chronic disease? Definition: high - it was there before the illness Term: treat anemia of chronic disease Definition: treat disease, iron will not help
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Term: Features of lead poisoning? Definition: pale, vague symptoms of irritability, lethargy, HAs, constipation, lead lines on long bones Term: treat lead poisoning.
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