Pharm 2

Pharm 2 - Term Definition Acetylcholine Direct acting...

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Term: Acetylcholine Definition: Direct acting muscarinic agonist, limited use for the treatment of glaucoma, very rapidly hydrolyzed by pseudocholinesterase Term: Carbachol Definition: Direct acting muscarinic agonist, analog of ACh, resistant to hydrolysis by chokinesterases, stimulates muscarinic and nicotinic receptors, topically used for glaucoma Term: Methacholine Definition: Direct acting muscarinic agonist, analog of ACh, stimulates muscarinic receptors, used in pulmonary function testing in asthma Term: Bethanechol Definition: Direct acting muscarinic agonist, pure muscarinic agonist, analog of ACh, resistant to rapid hydrolysis, stimulate GI motility and urinary retention Term: Pilocarpine Definition: Direct acting muscarinic agonist, used to treat glaucoma and xerostomia due to poor salivary secretion
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Term: Cevimeline Definition: Direct acting muscarinic agonist, used to treat salivary gland dysfunction Term: *muscarine Definition: Direct acting muscarinic agonist, natural product in some mushrooms, involved in poisoning, sxs include salivation, lacrimation, nausea, extreme GI hypermotility, bronchospasm, bradycardia, hypotension, and shock, treated with atropine Term: Edrophonium Definition: Reversible cholinesterase inhibitor, short acting, used in diagnosing myasthenia gravis, administer 2-8 mg dose, transient improvement supports Dx of myasthenia gravis, if sxs worsen indicative of excessive doses of cholinesterase inhibitors Term: Physostigmine Definition: Reversible cholinesterase inhibitor, nonquaternary ammonium compound (can get into CNS), used to treat poisoning with atropine or other antimuscarinic agents
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Term: Neostigmine Definition: Reversible cholinesterase inhibitor, quaternary ammonium compound, doesn't enter CNS, longer acting than edrophonium, used in treatment of myasthenia gravis Term: Methyldopa Definition: Action: must be converted to alpha-methyl norepinephrine. Alpha 2 adrenergic agonist, acts in central vasomotor center, dampens outflow of sympathetic nerve activity,decrease renin release, HR, arterial peripheral resistance falls. Tx of hypertension during pregnancy. Side effects: peripheral fluid retention, dry mouth, autoimmune disorders, hemolytic anemia, and abnormal liver function. Term: Pyridostigmine Definition: Reversible cholinesterase inhibitor, quaternary ammonium compound (does not enter CNS), longer acting than edrophonium, used in treatment of myasthenia gravis and to protect against nerve agents used in chemical warfare Term: Rivastigmine Definition: Reversible cholinesterase inhibitor, used in the treatment of Alzheimer's disease with modest improvement in cognitive ability
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Term: Donepezil Definition: Reversible cholinesterase inhibitor, used in the treatment of Alzheimer's disease with modest improvements in cognitive function Term: Carbamate insecticides Definition: Visible cholinesterase inhibitor, widely used insecticide, treat poisoning with atropine, pralidoxime is not useful in treating poisoning, used in treating lice Term: DFP/diisopropylfurophosphate/isoflur ophate Definition:
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