Anesthesia Drug Cards

Anesthesia Drug Cards - Term Definition PROPOFOL Diprivan...

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Term: PROPOFOL Definition: Diprivan Category: General anesthetic Use: induction of anesthesia greater than 3yo; maintenance of anesthesia in 2m or older, sedation for mechanically intubated patients in an ICU setting Unlabeled use: postop antiemetic, refractory delirium treatment Contraindications: hypersensitivity to propofol, eggs, soybeans/soy products (contains egg lecithin and soybean oil) Dose: 3-5 minutes between dosage changes, increase dose for chronic alcoholism, Onset 9-51 sec, Duration 3-10min Induction: Children 3-16 yo 2.5-3.5 mg/kg over 20-30 sec Adults: 2-2.5 mg/kg 40mg every 10 sec until onset of induction Elderly: 1-1.5 mg/kg 20mg every 10 sec. until onset of induction Maintenance: Children 2m-16yo 125-300 mcg/kg/min or 7.5-18 mg/kg/hr, children less than 5 may need larger doses Adults: 100-200 mcg/kg/min or 6-12 mg/kg/hr Elderly: 50-100 mcg/kg/min or 3-6 mg/kg/hr Boluses: 25-50 mg Precautions: hypersensitivity, anaphylaxis, angioedema, bronchospasm, hypotension, propofol related infusion syndrome (dysrhythmias, heart failure, rhabdo) Adverse Reactions: Hypotension, movement, burning at site of infusion, rash, hypertriglyceridemia, respiratory acidosis Mechanism of Action: global CNS
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depression possibly agonist actions of GABA receptors and reduced glutamatergic activity through NMDA receptor blockade Protein binding 97-99%, hepatic water soluble, renal excretion Half-life: initial 40 min; terminal 4-7 hrs.; 10+day infusion1-3 days Term: Rocuronium Definition: Zemuron Class: NDNMB Dose: Onset: 1-1.5 min Duration: 30-60 min Use: rapid sequence and routine intubation and skeletal muscle relaxant for surgery MOA: blocks acetylcholine from binding to receptors on motor endplate inhibiting depolarization Metabolism: hepatic (biliary excretion) Supplied: 10mg/ml Adverse Reactions: transient hypo/hypertension, arrhythmias, bronchospasms, hiccups, N/V, prolonged use acute quadriplegic myopathy syndrome, myositis ossificans Drug Interactions: cardiac glycosides, steroids, quinine Contraindications: prolonged 10-25 % renal and 70% hepatic disease
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Term: Cisatricurium Definition: Nimbex Class: Non Depolarizing NeuroMuscluar Blocker/cholinergic antagonist Dose: Infants/Children Intubation 0.1-.15 mg/kg Infusion .5-10 mcg/kg/min Adults Intubating 0.15-2 mg/kg Onset: 2-3m Duration: 20-35 min Use: adjunct to general anesthesia to facilitate intubation and relax skeletal muscle MOA: blocks neural transmission of the myoneural junction by binding w cholinergic receptors Metabolism: rapid nonenzymatic degradation in the bloodstream (Hofmann elimination) to laudanosine and inactive metabolites Half life: 22-29 minSupply: 2mg/ml Adverse Reactions: electrolyte imbalances, , myasthenia gravis, denervation, immobilization, bradycardia Drug Interactions: quinine, corticosteroids, cardiac glycoside Contraindications: sensitivity to cisatricurium
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Term: Succinylcholine Definition: Name: Succinylcholine/Anectine/Quelicin Category: depolarizing Muscle Relaxant Use: muscle paralysis Mechanism of Action: acts similar to acetocholine, producing depolarization at the motor endplate at the myoneural junction causing
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