Antifungals & Antivirals

Antifungals & Antivirals - Term Definition Ganciclovir...

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Term: Ganciclovir Definition: Activated by kinase phosphotransferase for CMV & thymidine kinase for HSV & VZV. Not a chain terminator but causes smaller, ineffective DNA fragments. Valganciclovir is the prodrug. Side effects are bone marrow suppression. Term: Side Effects for Ganciclovir Definition: Bone Marrow Suppression. Term: Cidofovir Definition: Cytosine nucleotide but it does not require viral activation. Coverage for HSV, VZV, CMV. Used for CMV resistant to other antivirals or patients who cannot tolerate side effects of ganciclovir (bone marrow suppression). Term: Foscarnet Definition: Inorganic pyrophosphate compound. Inhibits DNA polymerase, RNA polymerase, & HIV reverse transcriptase. Major use is CSV but can be used for HSV & VZV. Nephrotoxicity
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Term: Side effects of Acyclovir Definition: Headaches, crystallization in urine at high doses, neurotoxicity. Term: Drug of choice of CSV Definition: Ganciclovir or prodrug Valganciclovir. Bone Marrow suppression is side effect. IF patient cannot handle this drug you can use Cidofovir. Term: Acyclovir Definition: Activated by virus (thymidine kinase).
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