Cell and Tissue Biology

Cell and Tissue Biology - Term Definition Cells that form...

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Term: Cells that form platelets Definition: Megakaryocytes - sit next to the sinusoid lumen Term: What differentiates granulocytes from monocytes? Definition: 1. They have large lysosomes. 2. They have multi-lob nucleases with denser DNA Term: Easy way to ID eosinophils on slide Definition: They are packed with red/orange granules Term: How to ID basophil on slide Definition: They have lots of blue granules Term: Type of nucleus in monocytes Definition: "Kidney" or "horseshoe" nucleus with lots of active DNA
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Term: Gaucher's Disease Definition: Lose of glucocerebrosidase in the lysosome means that cell can't degrade glycolipid. Impairs hematopoiesis and it occurs in the liver and spleen instead of bone marrow Term: Diapedesis Definition: Leukocytes need to cross the endothelium barrier to get to tissue - chemotaxis, selectins, and integrins are involved Term: Glanzmann's thrombasthenia Definition: Platelets can't bind and form clot because of defect in integrin IIb/IIIa Term: Morph. Difference between monocyte and lymphocyte Definition: 1. Monocytes are larger; 2. Lymphocyte has higher N:C ratio
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Term: Shape of RBC and reason why Definition: Biconcave; 1. Increases surface area: volume ratio --> better for gas exchange; 2. Brings hemoglobin closer to the surface and cell periphery. 3. More flexible Term: Coating of particle to be phagocytosed Definition: Opsonized Term: What gives RBC its shape? Definition: Spectrin / actin structure connected to ankyrin, which is connected to plasma membrane via protein band 3 Term: Leukemia Definition: Higher WBC count. Acute (too many immature WBC) or chronic (too many chronic WBC). Lymphocytic vs. Myelocytic Term: Proteins in plasma Definition: Fibrinogen, albumins, globulins
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Term: Functions of Albumin Definition: Most abundant protein in blood - maintains osmotic pressure. Also binds and carries molecules. Term: What stimulates megakaryocyte proliferation and maturation Definition: The hormone thrombopoietin (Tpo) Term: SOX 9 Definition: gene important for chondrocyte formation Term: function of chondroblasts Definition: secret collagen II and proteoglycans to make the ECM Term: Appositional growth of cartilage Definition: stem cells in perichondrium add to cartilage
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Term: Interstitial growth for cartilage Definition: cells in the lacunae grow and make more ECM Term: Major type of collagen in cartilage Definition: Type II Term: Aggrecan Definition: An important proteoglycan in cartilage. Gives cartilage a negative charge Term: Keratan sulfate Definition: a GAG in Aggrecan (found in cartilage). Has a negative charge Term: chondroitin sulfate Definition: an important GAG in Aggrecan. Has a negative charge
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Term: Articular cartilage Definition: found in joints. Has different layers, despite thinness Term: Matrix metalloproteinase (MMP) Definition: plays a role in cartilage degradation.
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