Lecture 9 - Endocrine pathologies Bio416K Spring 08

Lecture 9 - Endocrine pathologies Bio416K Spring 08 -...

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Unformatted text preview: Endocrine Pathologies Three basic patterns of endocrine pathology: Hormone excess (hypersecretion) Hormone deficiency (hyposecretion) Abnormal tissue responsiveness to hormone (hyper- or hyporesponsiveness) Growth Hormone Pituitary dwarfism Pituitary gigantism Acromegaly Hyperprolactinemia Thyroid Hormone Graves’ disease Cretinism Adrenal cortex hormones Adrenal medulla hormones Cushing’s disease Pheochromocytoma Addison’s disease Insulin Gonadal steroid hormones Diabetes Type I Hypogonadism Diabetes Type II ADH Diabetes insipidus Pituitary Gigantism: Growth hormone (GH) hypersecretion in children results in gigantism as the still-active epiphyseal growth plates in bones are targeted by growth hormone. Individual becomes abnormally tall but has relatively normal body proportions. Hypersecretion commonly results from anterior pituitary tumor producing excessive amounts of growth hormone. Usual treatment is surgical removal of the tumor. Epiphyseal Growth Plate of Long Bones Pituitary Dwarfism Growth hormone hyposecretion in children results in deficient long bone growth and short stature. Growth hormone deficiency can also be associated with deficiencies of other anterior pituitary hormones. Growth hormone replacement therapy can promote nearly normal somatic growth Acromegaly Hypersecretion of growth hormone in adults after epiphyseal plates have closed. Characterized by overgrowth of the bones of the face, hands and feet, bony areas still responsive to growth hormone....
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Lecture 9 - Endocrine pathologies Bio416K Spring 08 -...

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