Lecture 12 - Chemical Signals and Neurotransmitters Bio416K Spring 08

Lecture 12 - Chemical Signals and Neurotransmitters Bio416K Spring 08

Info iconThis preview shows pages 1–4. Sign up to view the full content.

View Full Document Right Arrow Icon
Events at a Synapse
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Neurotransmitter Membrane Receptors Fall Into Two Categories 1. Ligand-gated (i.e., chemically-gated) ion channels (ICR) a. receptors alter ion channel function (ionotropic) - Fast synaptic potentials – EPSPs or IPSPs 1. G protein-linked receptors (GPCR) a. exert their actions through second messenger systems (metabotropic) b. some G protein-linked receptors alter ion channel activity - Slow synaptic potentials c. many channels called “leak channels” are actually gated channels that spend most of time in the open position. Second messengers can either open or close K + and Na + leak channels resulting in either EPSPs or IPSPs
Background image of page 2
Nervous System Uses a Variety of Neurotransmitters Seven structural classes of neurotransmitters 1. acetylcholine 2. amines (DA, E, NE, 5-HT) 3. lipids (eicosanoids) 4. amino acids (glutamate, GABA, glycine) 5. gases (NO, CO) 6. purines (adenosine, AMP, ATP) 7. peptides (endorphins, enkephalins, substance P) Largest variety of neurotransmitters are found in the CNS
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 4
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 03/20/2008 for the course BIO 416K taught by Professor Findell during the Spring '08 term at University of Texas at Austin.

Page1 / 22

Lecture 12 - Chemical Signals and Neurotransmitters Bio416K Spring 08

This preview shows document pages 1 - 4. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online