Notes - Chapter 11 - 062707

Notes - Chapter 11 - 062707 - Chapter 11 Regulation of gene...

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Chapter 11 – Regulation of gene expression in eukaryotes (Notes of material covered in class on 06/27/07) 1. Transcriptional regulation in eukaryotes – an overview - genome size is large; many more genes - role of chromatin and its reorganization - many more DNA sequence elements that regulate the expression of genes (cis-acting) - many more DNA-binding proteins (trans-acting) - combinatorial control results in a wide variety of patterns of gene expression 2. DNA sequence elements - promoter - promoter-proximal elements - promoter-distal elements – enhancers and insulators - enhancers – sites for binding of activator proteins for activation of transcription - insulators (or boundary elements) – found between enhancers and some promoters. Block activation of the promoter by activators bound at the enhancer. 3. DNA-binding proteins that regulate transcription (gene regulatory proteins) in eukaryotes consist of many of the following regions: - a domain that recognizes a DNA sequence (the protein’s DNA-binding site) – for example, helix-turn-helix, zinc finger, leucine zipper, etc
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Notes - Chapter 11 - 062707 - Chapter 11 Regulation of gene...

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