Cardiac_Physiology_2.ppt - Cardiac Physiology 2 Cardiac...

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Cardiac Physiology 2
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Cardiac Muscle Remember primarily involuntary only in the heart Mono-nucleated has own inherent rhythm and can contract without an external stimulus has faint striations and are branched gap junctions are common.
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Fig. 9-5, p. 246 Plasma membranes of adjacent cardiac muscle fibers Desmosome Gap junction Intercalated disc Action potential
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Pacemaker Potential and Cardiac Channels Potassium channel K+ permeability decreases between action potentials Sodium channel Not voltage gated Slow inward leak between action potentials T-type calcium channel Transient, opens before membrane threshold is reached Opens in the second half of the pacemaker potential L-type calcium channel Opens when threshold is reached Responsible for the rising phase
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Fig. 9-6, p. 247 Self-induced action potential Slow depolarization (pacemaker potential) Threshold potential NO HYPERPOLARIZATION
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Autorhythmic Cells; Nodes, Bundles and Fibers SA node- right atrial wall near the superior vena cava 70-80 bpm AV node Base of the right atrium near the septum 40-60 bpm Bundle of His
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